Romphruk A, Leelayuwat C, Barusrux S, Puapairoj C, Romphruk A, Urwijitaroon Y
Blood Transfusion Centre, Faculty of Medicine, Khon Kaen University, Thailand.
J Med Assoc Thai. 1997 Sep;80 Suppl 1:S13-9.
The phenotype and gene frequencies of HLA class I were studied in the Northeastern Thai population. Blood samples were collected from 100 unrelated healthy northeastern-Thais. HLA-A, -B and -Cw alleles were determined using the polymerase chain reaction- amplification refractory mutation system (PCR-ARMS). 12 HLA-A, 20 HLA-B and 14 HLA-Cw alleles were found. Linkage disequilibrium analysis indicated the existence of 7 HLA-A-B and 19 HLA-B-Cw haplotypes. A0207-Cw01-B*4601 was the most common possible haplotype in this population. These results provide regional basic information for further studies in anthropology, organ transplantation and MHC disease associations in the northeastern-Thais.
对泰国东北部人群的HLA I类分子的表型和基因频率进行了研究。从100名无亲缘关系的健康泰国东北部人采集血样。使用聚合酶链反应-扩增不应性突变系统（PCR-ARMS）确定HLA-A、-B和-Cw等位基因。共发现12个HLA-A等位基因、20个HLA-B等位基因和14个HLA-Cw等位基因。连锁不平衡分析表明存在7种HLA-A-B单倍型和19种HLA-B-Cw单倍型。A0207-Cw01-B*4601是该人群中最常见的可能单倍型。这些结果为泰国东北部人群在人类学、器官移植和MHC疾病关联方面的进一步研究提供了区域基础信息。
