志贺氏菌在侵袭上皮细胞过程中对细胞骨架进程的改变。
Diversion of cytoskeletal processes by Shigella during invasion of epithelial cells.
作者信息
Bourdet-Sicard R, Egile C, Sansonetti P J, Tran Van Nhieu G
机构信息
Unité de pathogénie microbienne moléculaire, Inserm U389, Institut Pasteur, Paris, France.
出版信息
Microbes Infect. 2000 Jun;2(7):813-9. doi: 10.1016/s1286-4579(00)90366-6.
Abstract
Shigella, the causative agent of bacillar dysentery, invades colonic epithelial cells and moves intracellularly to spread from cell to cell. The processes of Shigella entry, determined by the Ipa proteins, and of actin-based motility, dependent on the IcsA/VirG protein, represent different levels of bacterial manipulation of the cell cytoskeleton.
摘要
志贺氏菌是细菌性痢疾的病原体，它侵入结肠上皮细胞并在细胞内移动，从而实现细胞间传播。由Ipa蛋白决定的志贺氏菌进入过程以及依赖于IcsA/VirG蛋白的基于肌动蛋白的运动过程，代表了细菌对细胞骨架进行操控的不同层面。
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