Toy P H, Janda K D
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Acc Chem Res. 2000 Aug;33(8):546-54. doi: 10.1021/ar990140h.
Soluble polymers have been used as supports for reagent/catalyst immobilization and synthesis. Two polymers are commonly used in this context, linear polystyrene and poly(ethylene glycol). The complementary solubility properties of these polymers allow access to a wide range of chemistries. Parallel and combinatorial libraries of small molecules have been prepared using these polymers, and reagents/catalysts that are easily recovered and recycled have been immobilized on them. To develop soluble polymers with novel properties, bifunctional polymerization initiators have been used in a parallel combinatorial methodology to prepare block copolymers that exhibit unique solubility profiles.
可溶性聚合物已被用作固定试剂/催化剂和进行合成的载体。在这种情况下，通常使用两种聚合物，即线性聚苯乙烯和聚乙二醇。这些聚合物互补的溶解性使得能够进行多种化学反应。利用这些聚合物制备了小分子的平行和组合文库，并将易于回收和再循环的试剂/催化剂固定在它们上面。为了开发具有新特性的可溶性聚合物，双功能聚合引发剂已被用于一种平行组合方法中，以制备具有独特溶解特性的嵌段共聚物。
