Frey B A, Grisk O, Bandelow N, Wussow S, Bie P, Rettig R
Department of Physiology, Ernst Moritz Arndt University Greifswald, D-17495 Karlsburg, Germany.
Am J Physiol Regul Integr Comp Physiol. 2000 Sep;279(3):R1099-104. doi: 10.1152/ajpregu.2000.279.3.R1099.
Recipients of a kidney from spontaneously hypertensive rats (SHR) but not from normotensive Wistar-Kyoto rats (WKY) develop posttransplantation hypertension. To investigate whether renal sodium retention precedes the development of posttransplantation hypertension in recipients of an SHR kidney on a standard sodium diet (0.6% NaCl), we transplanted SHR and WKY kidneys to SHR x WKY F1 hybrids, measured daily sodium balances during the first 12 days after removal of both native kidneys, and recorded mean arterial pressure (MAP) after 8 wk. Recipients of an SHR kidney (n = 12) retained more sodium than recipients of a WKY kidney (n = 12) (7.3 +/- 10 vs. 4.0 +/- 0.7 mmol, P < 0.05). MAP was 144 +/- 6 mmHg in recipients of an SHR kidney and 106 +/- 5 mmHg in recipients of a WKY kidney (P < 0.01). Modest sodium restriction (0.2% NaCl) in a further group of recipients of an SHR kidney (n = 10) did not prevent posttransplantation hypertension (MAP, 142 +/- 4 mmHg). Urinary endothelin and urodilatin excretion rates were similar in recipients of an SHR and a WKY kidney. Transient excess sodium retention after renal transplantation may contribute to posttransplantation hypertension in recipients of an SHR kidney.
接受来自自发性高血压大鼠（SHR）而非正常血压的Wistar-Kyoto大鼠（WKY）的肾脏移植的受者，会在移植后出现高血压。为了研究在标准钠饮食（0.6% NaCl）下，SHR肾脏移植受者在移植后高血压发生之前是否存在肾钠潴留，我们将SHR和WKY的肾脏移植到SHR×WKY F1杂交种大鼠体内，在切除双侧自身肾脏后的前12天测量每日钠平衡，并在8周后记录平均动脉压（MAP）。接受SHR肾脏的受者（n = 12）比接受WKY肾脏的受者（n = 12）潴留更多的钠（7.3±10对4.0±0.7 mmol，P < 0.05）。接受SHR肾脏的受者的MAP为144±6 mmHg，接受WKY肾脏的受者的MAP为106±5 mmHg（P < 0.01）。另一组接受SHR肾脏的受者（n = 10）进行适度的钠限制（0.2% NaCl）并不能预防移植后高血压（MAP，142±4 mmHg）。接受SHR和WKY肾脏的受者的尿内皮素和尿舒张素排泄率相似。肾移植后短暂的钠潴留过多可能导致SHR肾脏移植受者出现移植后高血压。
