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两例腹主动脉瘤合并胆囊癌的偶发病例。影响动脉瘤和胆囊疾病患者治疗的更多数据。

Two incidental cases of abdominal aortic aneurysm and gallbladder cancer. Further data influencing the management of patients affected by aneurysm and gallbladder disease.

作者信息

De Monti M, Ghilardi G, Bianchi E, Kunkl E, Scorza R

机构信息

Chair of General Surgery, University of Milan.

出版信息

Minerva Cardioangiol. 2000 Apr-May;48(4-5):129-35.

Abstract

Abdominal aortic aneurysm and cholelithiasis are two common diseases in the elderly population. The prevalence of abdominal aortic aneurysms ranges between 1.8 and 6.6% in autoptic series and it's estimated that 2.5% of the over sixty year old population is affected. Carcinoma of the gallbladder is the most common malignant tumor of the biliary tract and in the United States is the fifth most frequent digestive tract malignancy; it's incidence ranges between 2 to 10 cases of 100,000 persons/year. No adequate guidelines are now available to assist the surgeon, in the case of concomitant gallbladder disease and abdominal aortic aneurysm. In this paper the management of abdominal aortic aneurysm in a patient with gallbladder disease is discussed in order to assist the surgeon deciding whether to perform concomitant aneurysm resection and cholecystectomy. In 162 aneurysmectomies (1987-1997) 18 (11.11%) patients underwent combined aneurysmectomy and cholecystectomy operation. The patients ranged in age from 49 to 88 years (average 69 years). In two cases the anatomo-histological specimen examinations (twelve sections) demonstrated a gallbladder carcinoma. The overall mortality rate was 5.56% either for aneurysmectomy alone or for combined therapy. In case of abdominal aortic aneurysm and concomitant gallbladder disease, in choosing simple endoaneurysmectomy, the surgeon has to consider the risk of early and late complications of leaving a diseased gallbladder in place. In case of concomitant performance of both operations, the risks of a possible septic graft contamination must be considered. We believe that the patient may be best served by performing the vascular and nonvascular procedures in the same operation. In this paper a new proof, till now never considered in the international literature, is presented to support our opinion: the possibility of concomitant unknown cancer or precancerous lesions in a lithiasic gallbladder. Diagnosis of these lesions is, indeed, not easy to perform in the preoperative phase and is often a postoperative anatomo-histological detection.

摘要

腹主动脉瘤和胆结石是老年人群中的两种常见疾病。在尸检系列中,腹主动脉瘤的患病率在1.8%至6.6%之间,据估计,60岁以上人群中有2.5%受到影响。胆囊癌是胆道最常见的恶性肿瘤,在美国是第五大常见的消化道恶性肿瘤;其发病率为每年每10万人中有2至10例。目前尚无足够的指南来协助外科医生处理合并胆囊疾病和腹主动脉瘤的情况。本文讨论了胆囊疾病患者腹主动脉瘤的处理方法,以协助外科医生决定是否同时进行动脉瘤切除术和胆囊切除术。在162例动脉瘤切除术中(1987 - 1997年),18例(11.11%)患者接受了动脉瘤切除术和胆囊切除术联合手术。患者年龄在49岁至88岁之间(平均69岁)。在两例中,解剖组织学标本检查(12个切片)显示为胆囊癌。单纯动脉瘤切除术或联合治疗的总死亡率均为5.56%。对于腹主动脉瘤合并胆囊疾病的情况,在选择单纯腔内动脉瘤切除术时,外科医生必须考虑保留患病胆囊所带来的早期和晚期并发症风险。在同时进行两种手术的情况下,必须考虑可能发生的人工血管感染风险。我们认为,在同一手术中进行血管和非血管手术可能对患者最为有利。本文提出了一个至今在国际文献中从未被考虑过的新证据来支持我们的观点:结石性胆囊中可能存在未知的癌症或癌前病变。事实上,这些病变在术前阶段不易诊断,通常是术后通过解剖组织学检测发现的。

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