Labo G, Miglio F, D'Ambro A, Bellobuono A, Ideo G, Dioguardi N, Bernardi M, Corazza G R, Gasbarrini G, Avogaro P, Pasquino M
Minerva Med. 1975 May 2;66(33):1590-4.
Two comparable groups of patients with hepatic cirrhosis of different genesis in a compensation phase have been treated for 30 days with S-adenosylmethionine and vitamine B-12 (28 cases) or with vitamine B-12 alone (25 cases). The drugs were given by slow intravenous route at the daily dose of 150 mg of SAMe and 2000 gamma of vit. B-12 or of 2000 gamma of vit. B-12 alone, in two adminstrations. An evaluation of the results was carried out mostly on the laboratory data testing the liver function. Only the group of patients who had received SAMe showed significant modifications of all the parameters considered. This is confirming SAMe ability to restore hepatocyte activity bringing also to normal the protein synthesis.
两组处于代偿期、病因不同的肝硬化患者分别接受了30天的治疗，一组使用S-腺苷甲硫氨酸和维生素B-12（28例），另一组仅使用维生素B-12（25例）。药物通过缓慢静脉注射给药，S-腺苷甲硫氨酸每日剂量为150毫克，维生素B-12为2000微克，或仅使用2000微克维生素B-12，分两次给药。主要根据检测肝功能的实验室数据对结果进行评估。只有接受S-腺苷甲硫氨酸治疗的患者组在所有考虑的参数上都有显著变化。这证实了S-腺苷甲硫氨酸恢复肝细胞活性并使蛋白质合成恢复正常的能力。
