Lösche W, Karapetow F, Pohl A, Pohl C, Kocher T
Research Centre for Vascular Biology and Medicine/Erfurt, Medical Faculty of the Friedrich-Schiller-University, Germany.
J Clin Periodontol. 2000 Aug;27(8):537-41. doi: 10.1034/j.1600-051x.2000.027008537.x.
Hyperlipidaemia and hyperglycaemia are major risk factors for cardiovascular disease. In recent years, some evidence has been presented that periodontal disease is associated with an increased risk of cardiovascular disease. To further elucidate this association, we have studied standard blood chemistry variables known as risk markers for cardiovascular disease in periodontally diseased and healthy subjects. We have measured levels of plasma lipids and fasting blood glucose in 39 subjects with moderate periodontal disease (age 50-60 years) and compared the results with those obtained in 40 age- and sex-matched controls. Both groups were systemically healthy according to their medical history. Total cholesterol, low density lipoprotein cholesterol and triglycerides were significantly higher in periodontally diseased subjects by about 8% (p<0.03), 13% (p<0.003) and 39% (p<0.001), respectively, when compared to controls. Although subjects with diabetes were excluded from the study, we found significantly higher blood glucose levels in the patient than in the control group (85 +/- 25 versus 73 +/- 17 mg/dl; p<0.02). There was also a significantly higher frequency of pathological plasma lipid profiles in the patient than in the control group. The results indicate that hyperlipaemia and pre-diabetes may be associated with periodontal disease in systemically healthy subjects. These data do not allow us to decide, whether periodontal disease causes an increase in hyperlipaemia and in a prediabetic state or whether periodontal disease and cardiovascular disease share hyperlipidaemia and the prediabetic state as common risk factors.
高脂血症和高血糖是心血管疾病的主要危险因素。近年来，有证据表明牙周病与心血管疾病风险增加有关。为进一步阐明这种关联，我们研究了牙周病患者和健康受试者中作为心血管疾病风险标志物的标准血液化学变量。我们测量了39名中度牙周病患者（年龄50 - 60岁）的血脂水平和空腹血糖，并将结果与40名年龄和性别匹配的对照组进行比较。根据病史，两组全身均健康。与对照组相比，牙周病患者的总胆固醇、低密度脂蛋白胆固醇和甘油三酯分别显著升高约8%（p<0.03）、13%（p<0.003）和39%（p<0.001）。虽然研究排除了糖尿病患者，但我们发现患者组的血糖水平显著高于对照组（85±25对73±17mg/dl；p<0.02）。患者组病理性血脂谱的频率也显著高于对照组。结果表明，高脂血症和糖尿病前期可能与全身健康受试者的牙周病有关。这些数据无法让我们确定是牙周病导致高脂血症和糖尿病前期状态增加，还是牙周病和心血管疾病共享高脂血症和糖尿病前期状态作为共同危险因素。
