Hay D W, Luttmann M A, Douglas S A
Department of Pulmonary Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, PA 19406, USA.
Br J Pharmacol. 2000 Sep;131(1):10-2. doi: 10.1038/sj.bjp.0703533.
The contractile profile of human urotensin-II (hU-II) was examined in primate airway and pulmonary vascular tissues. hU-II contracted tissues from different airway regions with similar potencies (pD(2)s from 8.6 to 9.2). However, there were regional differences in the efficacy of hU-II, with a progressive increase in the maximum contraction from trachea to smaller airway regions (from 9 to 41% of the contraction to 10 microM carbachol). hU-II potently contracted pulmonary artery tissues from different regions with similar potencies and efficacies: pD(2)s=8.7 to 9.3 and maximal contractions=79 to 86% of 60 mM KCl. hU-II potently contracted pulmonary vein preparations taken proximal to the atria, but had no effect in tissues from distal to the atria. This is the first report describing the contractile activity of hU-II in airways and suggests that the potential pathophysiological role of this peptide in lung diseases warrants investigation.
在灵长类动物气道和肺血管组织中检测了人尿紧张素II(hU-II)的收缩情况。hU-II使不同气道区域的组织收缩,效力相似(pD(2)值为8.6至9.2)。然而,hU-II的效力存在区域差异,从气管到较小气道区域,最大收缩逐渐增加(从对10 microM卡巴胆碱收缩的9%至41%)。hU-II使不同区域的肺动脉组织有力收缩,效力和效果相似:pD(2)值为8.7至9.3,最大收缩为60 mM氯化钾收缩的79%至86%。hU-II使心房近端的肺静脉制剂有力收缩,但对心房远端的组织无作用。这是首次描述hU-II在气道中收缩活性的报告,并表明该肽在肺部疾病中的潜在病理生理作用值得研究。