Antimalarial compounds. XIV. New derivatives of 2-bromo-N,N-bis-(diethylaminoethyl)-4,5-dimethoxyanaline (RC 12).

The molecule of RC 12 which was found previously to exhibit antimalarial activity has been modified, by replacing groups in positions 1 and 2 by NHAr, S-Ar, NO2, sulfonamido and other substituents. The new derivatives (Table 1) were tested for toxicity and antimalarial activity agains Plasmodium berghei in mice (Table 2).