Xu X, Weiss S, Xu X, Wei L J
Program for Population Genetics, Harvard School of Public Health, Boston, MA, 02115, USA.
Am J Hum Genet. 2000 Oct;67(4):1025-8. doi: 10.1086/303081. Epub 2000 Aug 28.
The Haseman and Elston (H-E) method uses a simple linear regression to model the squared trait difference of sib pairs with the shared allele identical by descent (IBD) at marker locus for linkage testing. Under this setting, the squared mean-corrected trait sum is also linearly related to the IBD sharing. However, the resulting slope estimate for either model is not efficient. In this report, we propose a simple linkage test that optimally uses information from the estimates of both models. We also demonstrate that the new test is more powerful than both the traditional one and the recently revisited H-E methods.
哈斯曼和埃尔斯顿（H-E）方法使用简单线性回归来建立同胞对性状差异平方的模型，该模型用于在标记位点进行连锁检验时，对同源相同等位基因（IBD）的同胞对进行分析。在这种情况下，经均值校正后的性状总和的平方也与IBD共享呈线性相关。然而，这两种模型得到的斜率估计都不是有效的。在本报告中，我们提出了一种简单的连锁检验方法，该方法能最佳地利用这两种模型估计值中的信息。我们还证明，新检验方法比传统方法和最近重新审视的H-E方法都更具效力。
