Koudela B, Modrý D, Volf J, Slapeta J R
Department of Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackého 1-3, 612 42, Brno, Czech Republic.
Vet Parasitol. 2000 Oct 1;92(3):191-8. doi: 10.1016/s0304-4017(00)00316-2.
Adult severe combined immunodeficient (SCID) mice were inoculated with oocysts of 13 different Caryospora (Protozoa, Apicomplexa) species isolated from the faeces of 10 reptilian and three raptorial bird hosts in attempt to test heteroxenous life cycle pattern. Only three reptilian isolates originated from viperid snakes, namely from Calloselasma rhodostoma, Atheris nitschei and Vipera ursinii induced lethal dermal caryosporosis in SCID mice. Neither clinical signs nor developmental stages were observed in mice infected with further nine caryosporan isolates originated from other reptilian and raptorial bird hosts. Results of this study confirmed that SCID mice represent a useful tool for evaluation of heteroxenous life cycle pattern of caryosporan coccidia and that only the Caryospora species from viperid and crotalid snakes produce dermal caryosporosis in mice
成年重度联合免疫缺陷（SCID）小鼠接种了从10种爬行动物和3种猛禽宿主粪便中分离出的13种不同梨形虫（原生动物，顶复门）物种的卵囊，试图测试异宿主生命周期模式。只有三种源自蝰蛇科蛇类的爬行动物分离株，即红口蝮、尼氏竹叶青和极北蝰，在SCID小鼠中诱发了致命的皮肤梨形虫病。感染源自其他爬行动物和猛禽宿主的另外九种梨形虫分离株的小鼠，既未观察到临床症状，也未观察到发育阶段。本研究结果证实，SCID小鼠是评估梨形虫球虫异宿主生命周期模式的有用工具，并且只有来自蝰蛇科和响尾蛇科蛇类的梨形虫物种会在小鼠中产生皮肤梨形虫病
