Wang L, Lubin J H, Zhang S R, Metayer C, Xia Y, Brenner A, Shang B, Wang Z, Kleinerman R A
Ministry of Health, China.
Int J Cancer. 2000 Oct 1;88(1):139-45. doi: 10.1002/1097-0215(20001001)88:1<139::aid-ijc22>3.0.co;2-l.
We report results from a population-based case-control study of lung cancer and environmental tobacco smoke (ETS) among never-smokers conducted in 2 rural prefectures of China, including 200 female and 33 male lung cancer cases, and 407 female and 114 male controls, matched on age, sex and prefecture of current residence. The odds ratio (OR) for ever-exposed to ETS was 1.19 (95% CI 0.7-2.0), with a significant trend (p<0.05) with increasing exposure. ORs were 1.00, 1.04, 1.13 and 1.51 for non-exposed, <10, 10-19 and >/=20 pack-years of ETS exposure, respectively. Excess risks were limited to ETS exposures in childhood (</=18 years of age). The OR for ever-exposed to ETS in childhood, adjusting for ETS exposure in adulthood, was 1. 52 (95% CI 1.1-2.2), with a significant trend (p<0.01) with increasing pack-years of childhood exposure, 1.00, 1.43, 1.81 and 2. 95, respectively. After adjustment for ETS in childhood, there was no excess risk from adult ETS exposure. The OR for ever-exposed to ETS in adulthood was 0.90 (95% CI 0.-1.4). These results were not affected by adjustment for type of residential dwelling, type or amount of fuel used, perceived indoor smokiness, or measures of socioeconomic status, or omitting next-of-kin respondents.
我们报告了一项在中国两个农村地区进行的基于人群的病例对照研究结果，该研究针对从不吸烟者的肺癌与环境烟草烟雾（ETS）展开，包括200例女性和33例男性肺癌病例，以及407例女性和114例男性对照，按照年龄、性别和现居住地区进行匹配。曾经暴露于ETS的比值比（OR）为1.19（95%可信区间0.7 - 2.0），且随着暴露增加存在显著趋势（p<0.05）。对于未暴露、<10、10 - 19以及≥20包年的ETS暴露，OR分别为1.00、1.04、1.13和1.51。额外风险仅限于儿童期（≤18岁）的ETS暴露。在调整成年期ETS暴露后，儿童期曾经暴露于ETS的OR为1.52（95%可信区间1.1 - 2.2），且随着儿童期暴露包年数增加存在显著趋势（p<0.01），分别为1.00、1.43、1.81和2.95。在调整儿童期ETS暴露后，成年期ETS暴露不存在额外风险。成年期曾经暴露于ETS的OR为0.90（95%可信区间0. - 1.4）。这些结果不受居住类型、使用燃料的类型或数量、感知到的室内烟雾程度、社会经济地位指标调整的影响，也不受遗漏近亲受访者的影响。
