含Src同源2结构域和Src同源3结构域的衔接蛋白Nck：一个双基因家族以及酪氨酸激酶与多个信号网络之间的连接物

The SH2 and SH3 adapter Nck: a two-gene family and a linker between tyrosine kinases and multiple signaling networks.

作者信息

Li W, She H

机构信息

The Department of Medicine and the Norris Cancer Center, The University of Southern California Medical School, Los Angeles 90033, USA.

出版信息

Histol Histopathol. 2000 Jul;15(3):947-55. doi: 10.14670/HH-15.947.

DOI:10.14670/HH-15.947

PMID:10963137

Abstract

SH2 and SH3 adapter proteins connect cell surface tyrosine kinases to intracellular signaling networks. For instance, the SH3-SH2-SH3 adapter Grb2 links receptor tyrosine kinases to the Ras pathway. Nck, composed of three SH3 domains and one SH2 domain, represents a two-gene (alpha and beta) family in mammals. Nckalpha and Nckbeta are expressed in the same cells and appear to have distinct signaling specificity. Studies show that Nck plays a role in cell mitogenesis and morphogenesis. The former uses Ras-dependent and Ras-independent pathways. The latter appears to coordinate with the Cdc42/Rac>PAK1/WASp>actin cytoskeleton pathway. Understanding the specificity of Nckalpha and Nckbeta signal transduction will provide answers for the previously often conflicting observations.

摘要

SH2和SH3衔接蛋白将细胞表面酪氨酸激酶与细胞内信号网络相连。例如，SH3-SH2-SH3衔接蛋白Grb2将受体酪氨酸激酶与Ras途径相连。Nck由三个SH3结构域和一个SH2结构域组成，在哺乳动物中代表一个双基因（α和β）家族。Nckα和Nckβ在相同细胞中表达，似乎具有不同的信号特异性。研究表明，Nck在细胞有丝分裂和形态发生中起作用。前者使用Ras依赖性和Ras非依赖性途径。后者似乎与Cdc42/Rac>PAK1/WASp>肌动蛋白细胞骨架途径协同作用。了解Nckα和Nckβ信号转导的特异性将为以前经常相互矛盾的观察结果提供答案。