黑色素瘤患者在接受α-2b干扰素治疗前经典和非经典HLA分子的表达分析
Expression analysis of classic and non-classic HLA molecules before interferon alfa-2b treatment of melanoma.
作者信息
Wagner S N, Rebmann V, Willers C P, Grosse-Wilde H, Goos M
出版信息
Lancet. 2000 Jul 15;356(9225):220-1. doi: 10.1016/S0140-6736(00)02486-7.
Abstract
Individual predictive clinical, immunological, or molecular features for definition of patients with lymph-node-positive melanoma who do not benefit from adjuvant postsurgery high-dose interferon alpha treatment are lacking. Expression analysis of classic and non-classic HLA molecules on melanoma cells metastatic to the locoregional lymph node may help select these patients before treatment.
摘要
目前缺乏用于定义淋巴结阳性黑色素瘤患者中哪些无法从辅助性术后高剂量干扰素α治疗中获益的个体预测性临床、免疫或分子特征。对转移至局部区域淋巴结的黑色素瘤细胞上经典和非经典HLA分子进行表达分析，可能有助于在治疗前筛选出这些患者。
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