丙二醇单甲醚（PGME）职业暴露。1. 通过分析尿液中的PGME进行生物监测。
Propylene glycol monomethyl ether (PGME) occupational exposure. 1. Biomonitoring by analysis of PGME in urine.
作者信息
Devanthéry A, Dentan A, Berode M, Droz P O
机构信息
Institut de santé au travail, Lausanne, Switzerland.
出版信息
Int Arch Occup Environ Health. 2000 Jul;73(5):311-5. doi: 10.1007/s004200000120.
An analytical method was developed for the determination of free and conjugated PGME-alpha in urine. The method involves a solid-phase extraction on LC-18 columns and a GC/FID analysis after derivatization with trimethysilylimidazole. The assay was linear (least-squares regression coefficient 0.996), specific, reproducible (intraassay variability 10%, interassay variability 10%), and allowed a high level of PGME recovery (more than 90%). The assay was applied to the analysis of urine samples from three workers who were occupationally exposed to PGME to estimate their exposure. The highest value of PGME concentration in urine was 7.78 mg/l. Air concentrations of PGME ranged between 20 and 40 ppm. A statistically significant correlation was found between measurements of external exposure and PGME in urine. An important fraction of PGME in urine was found to be conjugated.
开发了一种测定尿液中游离和结合型PGME-α的分析方法。该方法包括在LC-18柱上进行固相萃取，并用三甲基硅咪唑衍生化后进行气相色谱/火焰离子化检测分析。该测定方法呈线性（最小二乘回归系数为0.996）、具有特异性、可重复（批内变异为10%，批间变异为10%），并且PGME回收率较高（超过90%）。该测定方法应用于对三名职业性接触PGME的工人的尿液样本进行分析，以评估他们的接触情况。尿液中PGME的最高浓度值为7.78毫克/升。空气中PGME的浓度范围在20至40 ppm之间。发现外部接触测量值与尿液中的PGME之间存在统计学上的显著相关性。发现尿液中PGME的很大一部分是结合型的。
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