Pavlov K V, Sokolov V S
Frumkin Institute of Electrochemistry, Russian Academy of Sciences, Moscow.
Membr Cell Biol. 2000;13(6):745-88.
Experimental data on the ion electrogenic transport by Na+,K+-ATPase available in the literature are analyzed. Special attention is paid to the measurements of unsteady-state electric currents initiated by alternating voltage or rapid introduction of the substrate. In the final part, a physical model of the Na+,K+-ATPase functioning is discussed. According to this model, active transport is carried out by opening and closing of the access channels used for the sodium and potassium exchange between solutions on either side of the membrane. The model explains most of the experimental data, although some details (the channel size, rates of individual transport steps) need further refinement.
分析了文献中关于钠钾ATP酶离子电转运的实验数据。特别关注了由交流电压或快速引入底物引发的非稳态电流的测量。在最后一部分，讨论了钠钾ATP酶功能的物理模型。根据该模型，通过打开和关闭用于膜两侧溶液之间钠钾交换的通道来进行主动转运。该模型解释了大部分实验数据，尽管一些细节（通道大小、各个转运步骤的速率）需要进一步完善。
