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哥伦比亚卡塔赫纳和瑞士苏黎世癫痫手术项目的比较。

Comparison of the epilepsy surgery programs in Cartagena, Colombia, and Zürich, Switzerland.

作者信息

Tureczek I E, Fandiño-Franky J, Wieser H G

机构信息

Neurology Clinic, Department of Epileptology and EEG, University Hospital, Zürich, Switzerland.

出版信息

Epilepsia. 2000;41 Suppl 4:S35-40. doi: 10.1111/j.1528-1157.2000.tb01544.x.

Abstract

The organization, financing, productivity, quality of work, and cost-effectiveness of the Epilepsy Center in Cartagena, Colombia, were studied and compared with the epilepsy surgery program at the University Hospital Zürich, Switzerland. During a 2-month visit, one of the authors (I.T.) evaluated the center in Cartagena as a welfare institution and evaluated its epilepsy surgery program. The postoperative results of the Cartagena program were compared with those reported at the Second International Palm Desert Conference 1992, which revealed a similar rate of postoperative seizure control in temporal lobe epilepsy, slightly inferior results with hemispherectomy, and slightly better results with anterior callosotomy. A comparison between the two epilepsy centers showed that pre and postoperative antiepileptic drug treatment is more restricted in Colombia because of high costs. Although important diagnostic tools such as electroencephalography, seizure monitoring, neuropsychology, computed tomography, and magnetic resonance imaging are available in both centers, the Zürich program also has access to positron emission tomography, single photon emission computed tomography, magnetic resonance spectroscopy, and intracarotid and selective amobarbital tests. The postoperative seizure outcome is similar in surgical temporal lobe epilepsy patients (temporal lobectomy series, Cartagena; selective amygdalohippocampectomy series, Zürich). The comparison of direct costs of epilepsy surgery in Cartagena and Zürich showed that for the average patient undergoing epilepsy surgery in Cartagena, the cost is 5.5% of that in Zürich. This study presents evidence that epilepsy surgery is an inexpensive and efficient treatment option for epilepsy patients in developing countries. Epilepsy surgery in developing countries may even be considered at an early stage in patients who cannot afford the costs of lifetime medical treatment but can afford the one-time cost of a surgical treatment.

摘要

对哥伦比亚卡塔赫纳癫痫中心的组织架构、资金筹措、工作效率、工作质量及成本效益进行了研究,并与瑞士苏黎世大学医院的癫痫手术项目进行了比较。在为期两个月的访问期间,作者之一(I.T.)对卡塔赫纳的该中心作为福利机构进行了评估,并对其癫痫手术项目进行了评估。将卡塔赫纳项目的术后结果与1992年第二届国际棕榈泉沙漠会议报告的结果进行了比较,结果显示颞叶癫痫术后癫痫发作控制率相似,半球切除术结果略逊,前胼胝体切开术结果略好。两个癫痫中心的比较表明,由于成本高昂,哥伦比亚术前和术后抗癫痫药物治疗受到更多限制。虽然两个中心都有脑电图、癫痫发作监测、神经心理学、计算机断层扫描和磁共振成像等重要诊断工具,但苏黎世项目还可以使用正电子发射断层扫描、单光子发射计算机断层扫描、磁共振波谱以及颈内动脉和选择性异戊巴比妥试验。手术治疗的颞叶癫痫患者(卡塔赫纳的颞叶切除术系列;苏黎世的选择性杏仁核海马切除术系列)术后癫痫发作结果相似。卡塔赫纳和苏黎世癫痫手术直接成本的比较表明,在卡塔赫纳接受癫痫手术的普通患者,其成本是苏黎世的5.5%。这项研究表明,癫痫手术对于发展中国家的癫痫患者来说是一种成本低廉且有效的治疗选择。对于那些负担不起终身药物治疗费用但能负担得起一次性手术治疗费用的患者,甚至可以在早期就考虑在发展中国家进行癫痫手术。

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