Donnenberg M S
Department of Medicine, University of Maryland, Baltimore 21201, USA.
Nature. 2000 Aug 17;406(6797):768-74. doi: 10.1038/35021212.
Enteric bacteria use a limited array of macromolecular systems to implement diverse pathogenic strategies. The cellular targets of several enteric virulence factors have recently been identified. The themes that have emerged from these studies include the exploitation of molecules that regulate the actin cytoskeleton and the activation of apoptotic pathways to serve the pathogen.
肠道细菌利用有限的一系列大分子系统来实施多样的致病策略。最近已经确定了几种肠道毒力因子的细胞靶点。这些研究中出现的主题包括利用调节肌动蛋白细胞骨架的分子以及激活凋亡途径来为病原体服务。