致病诡计：对宿主细胞过程的欺骗

Pathogenic trickery: deception of host cell processes.

作者信息

Knodler L A, Celli J, Finlay B B

机构信息

Biotechnology Laboratory, Room 237-6174 University Boulevard, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3.

出版信息

Nat Rev Mol Cell Biol. 2001 Aug;2(8):578-88. doi: 10.1038/35085062.

DOI:10.1038/35085062

PMID:11483991

Abstract

Microbial pathogens cause a spectrum of diseases in humans. Although the disease mechanisms vary considerably, most pathogens have developed virulence factors that interact with host molecules, often usurping normal cellular processes, including cytoskeletal dynamics and vesicle targeting. These virulence factors often mimic host molecules, and mediate events as diverse as bacterial invasion, antiphagocytosis, and intracellular parastism.

摘要

微生物病原体可导致人类一系列疾病。尽管疾病机制差异很大，但大多数病原体都产生了与宿主分子相互作用的毒力因子，常常篡夺正常细胞过程，包括细胞骨架动力学和囊泡靶向运输。这些毒力因子常常模仿宿主分子，并介导诸如细菌入侵、抗吞噬作用和细胞内寄生等多种事件。