FGF-10诱导内源性和异位腺体形成。
Endogenous and ectopic gland induction by FGF-10.
作者信息
Govindarajan V, Ito M, Makarenkova H P, Lang R A, Overbeek P A
机构信息
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA.
出版信息
Dev Biol. 2000 Sep 1;225(1):188-200. doi: 10.1006/dbio.2000.9812.
FGF-10, a member of the fibroblast growth factor family, is expressed in mesodermally derived cell populations during embryogenesis. During normal ocular development, FGF-10 is expressed in the perioptic mesenchyme adjacent to the Harderian and lacrimal gland primordia. In this report, we provide evidence that FGF-10 is both necessary and sufficient to initiate glandular morphogenesis. Lens-specific expression of FGF-10 was sufficient to induce ectopic ocular glands within the cornea. In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis.
成纤维细胞生长因子10（FGF - 10）是成纤维细胞生长因子家族的一员，在胚胎发育过程中于中胚层来源的细胞群体中表达。在正常的眼部发育过程中，FGF - 10在紧邻哈德氏腺和泪腺原基的视周间充质中表达。在本报告中，我们提供证据表明FGF - 10对于启动腺体形态发生既是必要的也是充分的。FGF - 10在晶状体中的特异性表达足以在角膜内诱导异位眼腺。此外，在FGF - 10基因敲除的胎儿中未观察到泪腺和哈德氏腺。基于这些结果，我们提出FGF - 10是一种启动眼腺形态发生的诱导信号。
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