Schnog J B, Keli S O, Pieters R A, Rojer R A, Duits A J
Department of Internal Medicine, St. Elisabeth Hospital, Curaçao, Netherlands Antilles.
Clin Immunol. 2000 Sep;96(3):264-8. doi: 10.1006/clim.2000.4884.
The red blood cell Duffy antigen receptor for chemokines serves as a sink for the clearance of chemokines such as interleukin-8 (IL-8) from the circulation. We analyzed the impact of the Duffy phenotype on sickle cell disease (SCD) severity and serum IL-8 levels in 15 Duffy-positive and 36 Duffy-negative sickle cell patients. There was no difference in clinical severity between Duffy-positive and Duffy-negative sickle cell patients. In asymptomatic sickle cell patients the upward deviation of mean serum IL-8 levels was significantly greater in Duffy-negatives (n = 20) than in Duffy-positives (n = 8) (P = 0.011). However, during a vasoocclusive episode, serum IL-8 levels were similar between Duffy-negatives (n = 11) and Duffy-positives (n = 3). Although the Duffy phenotype seems to influence steady-state serum IL-8 levels, it does not seem to have an effect on SCD severity.
趋化因子的红细胞达菲抗原受体可作为从循环中清除趋化因子（如白细胞介素-8，IL-8）的一个“汇”。我们分析了达菲血型对15名达菲阳性和36名达菲阴性镰状细胞病（SCD）患者疾病严重程度及血清IL-8水平的影响。达菲阳性和达菲阴性镰状细胞病患者的临床严重程度并无差异。在无症状镰状细胞病患者中，达菲阴性患者（n = 20）的平均血清IL-8水平向上偏离程度显著大于达菲阳性患者（n = 8）（P = 0.011）。然而，在血管闭塞发作期间，达菲阴性患者（n = 11）和达菲阳性患者（n = 3）的血清IL-8水平相似。尽管达菲血型似乎会影响稳态血清IL-8水平，但它似乎对SCD严重程度没有影响。
