Mulcahy J J, Malvin R L
Vox Sang. 1975;29(4):237-41. doi: 10.1111/j.1423-0410.1975.tb00503.x.
Measurement of plasma volume before and after the acute infusion of commercial dextran revealed that all brands tested were hyperoncotic by a factor of approximately 2. By mixing 6% dextran with 0.9% saline in 1:1 proportion a 3% dextran solution was obtained which was nearly isoncotic in our dogs. The most likely explanation for the discrepancy is that the 6% solution contains a high proportion of molecules of lower molecular weight resulting in a greater oncotic pressure than predicted on the basis of the average molecular weight. In addition, this leads to a rapid loss of this solute from the blood. Clinicians and researchers should be aware of the possibility that the dextran preparation they are using is not truly isoncotic.
对商用右旋糖酐进行急性输注前后的血浆容量测量显示，所有测试品牌的胶体渗透压均约为正常的2倍。将6%的右旋糖酐与0.9%的生理盐水按1:1比例混合，得到了一种3%的右旋糖酐溶液，该溶液在我们的实验犬体内几乎为等渗。这种差异最可能的解释是，6%的溶液含有高比例的低分子量分子，导致其胶体渗透压高于基于平均分子量预测的数值。此外，这会导致该溶质从血液中快速流失。临床医生和研究人员应意识到他们所使用的右旋糖酐制剂并非真正等渗的可能性。
