Hari D, Beckett M A, Sukhatme V P, Dhanabal M, Nodzenski E, Lu H, Mauceri H J, Kufe D W, Weichselbaum R R
Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637, USA.
Mol Cell Biol Res Commun. 2000 May;3(5):277-82. doi: 10.1006/mcbr.2000.0222.
Angiostatin is an inhibitor of tumor angiogenesis that induces regression of experimental tumors and enhances the antitumor effects of radiation therapy. We report that the cytotoxic effects of angiostatin are restricted to the proliferating endothelial cell population. In addition, angiostatin and ionizing radiation (IR) interact by inducing death of dividing endothelial cells. We also show that angiostatin and IR interact to inhibit endothelial cell migration. These findings demonstrate that angiostatin targets the proliferating tumor vasculature and provide a mechanistic basis for the cytotoxic interaction of angiostatin and IR.
血管抑素是一种肿瘤血管生成抑制剂，可诱导实验性肿瘤消退并增强放射治疗的抗肿瘤效果。我们报告血管抑素的细胞毒性作用仅限于增殖的内皮细胞群体。此外，血管抑素与电离辐射（IR）相互作用，诱导正在分裂的内皮细胞死亡。我们还表明，血管抑素与IR相互作用以抑制内皮细胞迁移。这些发现表明血管抑素靶向增殖的肿瘤脉管系统，并为血管抑素与IR的细胞毒性相互作用提供了机制基础。
