Tommasino C, De Felice L, Colombo S, Salaris D, Capocasa T, Giudici D
Cattedra di Anestesiologia e Rianimazione, IRCCS H San Raffaele, Università degli Studi, Milano.
Minerva Anestesiol. 2000 Jul-Aug;66(7-8):555-9.
Retinoic acid syndrome is a potentially life-threatening complication of therapy for acute promyelocytic leukemia (APL) with all-transretinoic acid (ATRA). The case of a 55-year old male patient admitted to the hospital because of a bleeding diathesis is reported. APL was diagnosed and he underwent treatment with idarubicin and ATRA (GIMEMA protocol); 24 hrs after ATRA treatment he developed retinoic acid syndrome and was admitted to the Intensive Care Unit because of severe respiratory insufficiency (dyspnoea, tachypnea and severe hypoxemia (SpO2 75%). Pulmonary insufficiency was treated non-invasively with CPAP and the patient recovered from pulmonary distress one week later.
维甲酸综合征是全反式维甲酸（ATRA）治疗急性早幼粒细胞白血病（APL）时一种潜在的危及生命的并发症。本文报道了一名55岁男性患者，因出血倾向入院。该患者被诊断为APL，并接受了伊达比星和ATRA治疗（GIMEMA方案）；ATRA治疗24小时后，他出现了维甲酸综合征，因严重呼吸功能不全（呼吸困难、呼吸急促和严重低氧血症（血氧饱和度75%））入住重症监护病房。采用持续气道正压通气（CPAP）对肺功能不全进行无创治疗，患者一周后从肺部窘迫中康复。
