Anim-Nyame N, Sooranna S R, Steer P J, Johnson M R
Department of Maternal-Fetal Medicine, Division of Paediatrics, Obstetrics & Gynaecology, Imperial College School of Medicine, Chelsea & Westminster Hospital, London, UK.
Hum Reprod. 2000 Sep;15(9):2033-6. doi: 10.1093/humrep/15.9.2033.
Leptin concentrations have been found to be elevated in cross-sectional studies of established pre-eclampsia. Circulating concentrations of leptin were measured in a cross-sectional study to confirm these findings (19 women with pre-eclampsia and 13 normal pregnant controls) and in a longitudinal study to establish the timing of the increase in leptin concentrations (samples obtained at 16, 20, 24, 28, 32, 36 and 38 weeks gestation from eight women who went on to develop pre-eclampsia and seven normal pregnant controls). In the cross-sectional study, plasma leptin concentrations were significantly greater in women with pre-eclampsia than in normal controls (P: = 0.001). In the longitudinal study, it was found that circulating leptin concentrations rose gradually to 32 weeks and thereafter declined slightly in normals. The concentrations in women destined to develop pre-eclampsia were consistently higher from 20 weeks gestation (P: = 0.04-0.003) and, in contrast to the normal controls, rose markedly from 32 weeks as pre-eclampsia developed. This study confirms that plasma leptin concentrations are increased in established pre-eclampsia and reports for the first time that leptin concentrations are elevated before pre-eclampsia is clinically evident.
在已确诊的子痫前期横断面研究中发现瘦素浓度升高。在一项横断面研究中测量了循环瘦素浓度以证实这些发现（19例子痫前期患者和13例正常妊娠对照），并在一项纵向研究中确定瘦素浓度升高的时间（从8例后来发展为子痫前期的女性和7例正常妊娠对照在妊娠16、20、24、28、32、36和38周时采集样本）。在横断面研究中，子痫前期女性的血浆瘦素浓度显著高于正常对照（P = 0.001）。在纵向研究中，发现正常妊娠者循环瘦素浓度逐渐上升至32周，此后略有下降。注定要发展为子痫前期的女性从妊娠20周起浓度持续较高（P = 0.04 - 0.003），与正常对照不同，随着子痫前期的发展，从32周起浓度显著上升。这项研究证实已确诊的子痫前期患者血浆瘦素浓度升高，并首次报告在子痫前期临床症状出现之前瘦素浓度就已升高。
