Griendling K K, Ushio-Fukai M
Division of Cardiology, School of Medicine, Emory University, 319 WMB, 1639 Pierce Drive, 30322, Atlanta, GA 30322, USA.
Regul Pept. 2000 Jul 28;91(1-3):21-7. doi: 10.1016/s0167-0115(00)00136-1.
Angiotensin II stimulates a plethora of signaling pathways leading to cell growth and contraction. Recent work has shown that reactive oxygen species are involved in transducing many of the effects of angiotensin II, and are in fact produced in response to agonist-receptor binding. Angiotensin II stimulates a NAD(P)H oxidase to produce superoxide and hydrogen peroxide, both of which may act on intracellular growth-related proteins and enzymes to mediate the final physiological response. Of particular importance is hydrogen peroxide, which mediates angiotensin II stimulation of such important intracellular signals as EGF-receptor transactivation, p38 mitogen activated protein kinase, and Akt. Future work will be directed towards identifying other important redox-sensitive signaling pathways and their relationship to the physiology and pathophysiology of the renin-angiotensin system.
血管紧张素II刺激大量导致细胞生长和收缩的信号通路。最近的研究表明，活性氧参与了血管紧张素II的许多效应转导，并且实际上是在激动剂与受体结合后产生的。血管紧张素II刺激NAD(P)H氧化酶产生超氧化物和过氧化氢，这两者都可能作用于细胞内与生长相关的蛋白质和酶，以介导最终的生理反应。特别重要的是过氧化氢，它介导血管紧张素II对诸如表皮生长因子受体转活化、p38丝裂原活化蛋白激酶和Akt等重要细胞内信号的刺激。未来的工作将致力于确定其他重要的氧化还原敏感信号通路及其与肾素-血管紧张素系统生理和病理生理的关系。
