Mon Y, Nakamura N
Department of Neurology, Kyoto-min-iren Dai-ni Chuo Hospital.
Rinsho Shinkeigaku. 2000 Apr;40(4):364-6.
Here we present a case of velopharyngeal palsy. An 18-year-old man had hyperemia in his left conjunctivum. One or two weeks later he experienced nasal speech and difficulty in swallowing. General physical examination was normal. The only abnormal neurological finding was palato-pharyngeal paralysis on the right side. MRI of the head and neck had no abnormalities. Acute and convalescent sera showed no rise in viral antibody titer. CSF examination was normal except for the increased IgG% and IgG.albumin index. Treatment consisted of glycerol and steroid, and his symptom improved within two or three weeks. We think immunological mechanism is important because CSF examination showed increased IgG% and IgG.albumin index in our case. Acquired and isolated velopharyngeal palsy is uncommon. Only 26 cases have been reported so far. This is the first case in Japan. The disease has some characteristics. This occurs in childhood and adolescence. Onset is sudden, consisting in rhinolalia and dysphagia. On examination there is asymmetry of the pharynx and deviation of the uvula contralateral to the affected side. There is no other neurological abnormalities. Complete spontaneous recovery is usual. In some cases viral infection is the cause, but in most cases the cause is unknown. In contrast, the disease with both acquired velopharyngeal palsy and vocal cord palsy is relatively common. This occurs in the middle aged or elderly people. In addition to dysphagia and hoarse voice, this disease often accompanies neurological abnormalities such as other cranial nerve palsy and meningitis, fever, and pain in the pharyngeal region. In most cases viral infection is the cause.
在此,我们呈现一例腭咽麻痹病例。一名18岁男性左侧结膜充血。一两周后,他出现鼻音和吞咽困难。全身体格检查正常。唯一异常的神经学表现是右侧腭咽麻痹。头颈部MRI未见异常。急性期和恢复期血清病毒抗体滴度均未升高。脑脊液检查除IgG%和IgG.白蛋白指数升高外均正常。治疗包括使用甘油和类固醇,其症状在两到三周内有所改善。我们认为免疫机制很重要,因为在我们的病例中脑脊液检查显示IgG%和IgG.白蛋白指数升高。获得性孤立性腭咽麻痹并不常见。迄今为止仅报道了26例。这是日本的首例病例。该疾病具有一些特点。它发生于儿童期和青少年期。起病突然,表现为鼻音和吞咽困难。检查可见咽部不对称,悬雍垂偏向患侧对侧。无其他神经学异常。通常可完全自发恢复。在某些情况下,病毒感染是病因,但在大多数情况下病因不明。相比之下,同时伴有获得性腭咽麻痹和声带麻痹的疾病相对常见。它发生于中年或老年人。除吞咽困难和声音嘶哑外,该疾病常伴有其他颅神经麻痹、脑膜炎、发热及咽部疼痛等神经学异常。在大多数情况下,病毒感染是病因。