Lory P, Monteil A, Chemin J, Leuranguer V, Bourinet E, Nargeot J
Physiopathologie des Canaux Ioniques, IGH-CNRS UPR 1142, Montpellier, France.
Therapie. 2000 Mar-Apr;55(2):249-54.
Voltage-gated calcium channels are involved in a large variety of cellular functions such as excitation-contraction coupling, hormone secretion, firing and pacemaker activity, gene activation and proliferation. Cloning of complementary DNAs encoding for calcium channel subunits has challenged the study of the functional properties of calcium channels and has allowed analysis of the molecular basis of calcium channel diversity. Recently, pore-forming subunits of T-type calcium channels have been cloned. Recent data describing the genes encoding calcium channels, their molecular and pharmacological studies, as well as their linkage to human genetic diseases are reviewed in this article.
电压门控钙通道参与多种细胞功能，如兴奋-收缩偶联、激素分泌、放电和起搏活动、基因激活和增殖。编码钙通道亚基的互补DNA的克隆对钙通道功能特性的研究提出了挑战，并使得对钙通道多样性的分子基础进行分析成为可能。最近，T型钙通道的孔形成亚基已被克隆。本文综述了描述钙通道编码基因、其分子和药理学研究以及它们与人类遗传疾病联系的最新数据。
