Goel K M, Shanks R A, Whaley K, Mason M, MacSween R N
Arch Dis Child. 1975 Jun;50(6):419-23. doi: 10.1136/adc.50.6.419.
The prevalence of nine serum autoantibodies has been studied in 117 children with various connective tissue disorders and in 134 normal controls. In juvenile rheumatoid arthritis rheumatoid factor was present in 5%, and antinuclear factor in 4%, compared with an incidence of 4% and 0% respectively in controls. In Henoch-Schönlein purpura there was little evidence of associated autoimmune disorder. Gastric parietal cell and thyroid microsomal antibodies were found in 9% and 10% of our control population, but the significance of this is not clear. It is concluded that in children the presence or absence of autoantibodies as diagnostic criteria should be interpreted with the greatest caution.
对117名患有各种结缔组织疾病的儿童和134名正常对照者的9种血清自身抗体的患病率进行了研究。在青少年类风湿性关节炎中，类风湿因子的出现率为5%，抗核因子为4%，而对照组的发生率分别为4%和0%。在过敏性紫癜中，几乎没有相关自身免疫性疾病的证据。在我们的对照人群中，胃壁细胞抗体和甲状腺微粒体抗体的发现率分别为9%和10%，但其意义尚不清楚。得出的结论是，在儿童中，作为诊断标准的自身抗体的存在与否应极其谨慎地加以解释。
