Andrade P M, Baracat E C, Simões M J, Rodrigues de Lima G
Department of Gynecology, Federal University of São Paulo, SP, Brazil.
Clin Exp Obstet Gynecol. 2000;27(2):138-41.
The aim of this study was to analyse the morphologic and morphometric aspects of endometrium in rats receiving hormone replacement therapy with conjugated equine estrogen (CEE), medroxyprogesterone acetate (MPA) and tamoxifen (TMX). Thirty-five adults rats, 2-3 months of age were ovariectomized four days prior to using the drugs. Rats were divided according to the following treatments for 60 days: CEE (50 microg); CEE/MPA (50 microg/2 mg); MPA (2mg); TMX (250 microg); vehicle (propyleneglycol). Fragments of endometrium were removed and analysed by light microscopy. The endometrium suffered evident morphologic modifications under the action of hormones and TMX. The endometrium was significantly thicker in the CEE, CEE/MPA and TMX group when compared to the control, however the MPA group showed no differences when compared to the control group.
本研究的目的是分析接受结合马雌激素（CEE）、醋酸甲羟孕酮（MPA）和他莫昔芬（TMX）激素替代疗法的大鼠子宫内膜的形态学和形态计量学方面。35只2至3月龄的成年大鼠在用药前4天进行卵巢切除。大鼠根据以下治疗方案分为几组，持续60天：CEE（50微克）；CEE/MPA（50微克/2毫克）；MPA（2毫克）；TMX（250微克）；赋形剂（丙二醇）。取出子宫内膜碎片并通过光学显微镜进行分析。在激素和TMX的作用下，子宫内膜出现明显的形态学改变。与对照组相比，CEE、CEE/MPA和TMX组的子宫内膜明显更厚，然而MPA组与对照组相比无差异。
