Leitch C A, Karn C A, Ensing G J, Denne S C
Department of Pediatrics, Section of Neonatal-Perinatal Medicine, Indiana University School of Medicine, Indianapolis, USA.
J Pediatr. 2000 Sep;137(3):381-5. doi: 10.1067/mpd.2000.107844.
Infants with cyanotic congenital heart disease (CCHD) have previously been shown to have similar resting energy expenditures (REEs) and elevated total energy expenditures (TEEs) compared with age-matched healthy infants. The purpose of this investigation was to re-examine the REE and TEE of the same individuals at 5 years of age, after surgical repair of the heart defect was done, to determine whether metabolic differences persist.
Seven children were studied approximately 2.6 years after they underwent surgical repair of CCHD along with 10 age-matched healthy children. Indirect calorimetry was used to determine REE, and the doubly labeled water method was used to determine TEE and body composition.
Results were compared with single-factor repeated measures analysis of variance. No significant differences were found between groups in weight or body composition. No significant differences were found between groups in REE, TEE, or the energy expended in physical activity.
We conclude that differences in TEE observed during infancy are no longer present in 5-year-old children after they undergo surgical repair of CCHD. Furthermore, the individual components of energy expenditure of children with CCHD after repair are indistinguishable from those of healthy age-matched children.
先前研究表明，与年龄匹配的健康婴儿相比，患有青紫型先天性心脏病（CCHD）的婴儿静息能量消耗（REE）相似，但总能量消耗（TEE）升高。本研究的目的是在心脏缺陷手术修复后，重新检查同一批个体在5岁时的REE和TEE，以确定代谢差异是否持续存在。
对7名接受CCHD手术修复后约2.6年的儿童以及10名年龄匹配的健康儿童进行了研究。采用间接测热法测定REE，采用双标水法测定TEE和身体成分。
采用单因素重复测量方差分析对结果进行比较。两组在体重或身体成分方面未发现显著差异。两组在REE、TEE或体力活动消耗的能量方面也未发现显著差异。
我们得出结论，患有CCHD的婴儿期观察到的TEE差异在5岁儿童接受CCHD手术修复后不再存在。此外，修复后CCHD患儿能量消耗的各个组成部分与年龄匹配的健康儿童没有区别。
