Lurie A G, Cutler L S
J Natl Cancer Inst. 1979 Jul;63(1):147-52.
The effects of repeated low-dose-rate, high-dose-rate X-radiation of the head and neck on lingual tumor induction by 7,12-dimethylbenz[a]anthracene (DMBA) in Syrian golden hamsters were studied. Animals received either topical application as 0.5% DMBA in acetone on the lateral middle third of the tongue three times a week for 15 consecutive weeks, 20-R X-radiation exposures of the head and neck once a week for 15 consecutive weeks, or concurrent radiation and DMBA treatments for 15 consecutive weeks. Animals were examined visually at regular intervals, and all were killed 35 weeks after the start of treatments. All tissues were than examined histopathologically. Animals receiving radiation alone had no detectable changes. Animals receiving DMBA plus radiation had an excess of papillomas compared to animals receiving only DMBA (35% vs. 15%). In addition, an excess of nonlingual oral tumors (lip, gingiva, and floor of mouth) was found in DMBA-treated plus radiation-treated animals versus DMBA-treated animals. These results suggest that repeated, localized, low-level X-radiation exposures enhance chemical tumorigenesis in a variety of oral tissues of Syrian golden hamsters.
研究了反复低剂量率、高剂量率头部和颈部X射线辐射对叙利亚金仓鼠舌部肿瘤诱发的影响，该肿瘤由7,12-二甲基苯并[a]蒽（DMBA）诱发。动物接受以下处理之一：连续15周每周3次在舌外侧中三分之一处局部涂抹丙酮中0.5%的DMBA；连续15周每周1次对头部和颈部进行20-R X射线辐射；或连续15周同时进行辐射和DMBA处理。定期对动物进行肉眼检查，所有动物在处理开始35周后处死。然后对所有组织进行组织病理学检查。仅接受辐射的动物未发现可检测到的变化。与仅接受DMBA的动物相比，接受DMBA加辐射的动物乳头状瘤过多（35%对15%）。此外，与仅接受DMBA处理的动物相比，接受DMBA加辐射处理的动物非舌部口腔肿瘤（唇、牙龈和口腔底部）过多。这些结果表明，反复、局部、低水平的X射线辐射暴露会增强叙利亚金仓鼠多种口腔组织中的化学致癌作用。
