Mitra S K, Rangesh P R, Venkataranganna M V, Udupa U V, Gopumadhavan S, Seshadri S J
R&D Centre, The Himalaya Drug Company, Makali, Bangalore, India.
Phytomedicine. 2000 Jul;7(4):265-72. doi: 10.1016/S0944-7113(00)80043-4.
In the present study the efficacy of OST-6 (OsteoCare), a herbomineral preparation, on bone mineralization in experimental rickets has been evaluated. This was accomplished by feeding pregnant rats and subsequently their pups with vitamin D and calcium deficient (VDCD) with low phosphorus diet. The parameters such as serum and bone mineral contents (calcium and inorganic phosphorus), serum alkaline phosphatase, sex hormones and histology of bone were considered. VDCD resulted in a significant reduction in bone and serum calcium and inorganic phosphorus, increased serum alkaline phosphatase and decreased sex hormones (testosterone in males, progesterone and oestrogen in females). Histologically the bone showed osteodystrophic changes and disproportionate cartilaginous proliferations in the epiphyseal region. Incorporation of OST-6 into feed at 5% concentration resulted in a complete reversal of rickets, which was substantiated by biochemical and histological observations. It has been concluded that OST-6 is useful in the management of rickets in a natural way through herbal resources.
在本研究中，已对一种草药矿物质制剂OST-6（骨宝）对实验性佝偻病骨矿化的功效进行了评估。这是通过用低磷饮食喂养维生素D和钙缺乏（VDCD）的怀孕大鼠及其幼崽来实现的。研究考虑了血清和骨矿物质含量（钙和无机磷）、血清碱性磷酸酶、性激素以及骨组织学等参数。VDCD导致骨和血清钙以及无机磷显著降低，血清碱性磷酸酶升高，性激素降低（雄性为睾酮，雌性为孕酮和雌激素）。组织学上，骨显示出骨营养不良性改变以及骨骺区域软骨过度增生。以5%的浓度将OST-6添加到饲料中可使佝偻病完全逆转，这一点得到了生化和组织学观察结果的证实。得出的结论是，OST-6可通过草药资源以自然方式有效治疗佝偻病。
