Cooper M D, Lawton A R
Birth Defects Orig Artic Ser. 1975;11(1):3-6.
The development of IgM-, IgG- and then IgA-bearing B lymphocytes is an orderly process occurring independently of antigens and T cells. T cells enhance antigen-induced B lymphocyte to plasma cell differentiation according to the hierarchy: IgA greater than IgG greater than IgM. T cells also exhibit antigenindependent and dependent stages of differentiation and a functional diversity, perhaps attributable to different classes of T cells. New evidence indicates the presence of a receptor on T cells for IgM antibody produced by B cells.
携带IgM、IgG继而IgA的B淋巴细胞的发育是一个独立于抗原和T细胞发生的有序过程。T细胞根据以下层次增强抗原诱导的B淋巴细胞向浆细胞的分化：IgA大于IgG大于IgM。T细胞也表现出分化的抗原非依赖和依赖阶段以及功能多样性，这可能归因于不同类别的T细胞。新证据表明T细胞上存在针对B细胞产生的IgM抗体的受体。
