Manning M A, Cardinale R M, Schmidt-Ullrich R K, Kavanagh B D, Wornom I L, Broaddus W C
Department of Radiation Oncology, Medical College of Virginia Hospitals, Virginia Commonwealth University, Richmond 23298-0058, USA.
J Neurosurg. 2000 Sep;93(3):494-7. doi: 10.3171/jns.2000.93.3.0494.
This patient with recurrent meningioma grossly involving the frontal bone underwent craniotomy and tumor resection. During the procedure a bone flap was irradiated extracorporeally at a very high dose (120 Gy) sufficient to sterilize residual tumor cells, and the bone was then successfully replaced orthotopically for reconstruction. The use of autologous irradiated bone in this setting offers advantages over cadaveric transplantation and prosthetic implants. Radiation might cause less disruption of the bone's architecture than other techniques of tumor cell eradication.
这位患有复发性脑膜瘤且肿瘤明显累及额骨的患者接受了开颅手术和肿瘤切除术。手术过程中，一块骨瓣在体外接受了非常高剂量（120 Gy）的照射，足以杀灭残留的肿瘤细胞，然后该骨瓣成功原位复位用于重建。在这种情况下使用自体照射骨比尸体移植和假体植入具有优势。与其他肿瘤细胞根除技术相比，放疗可能对骨结构的破坏更小。
