肉桂醛抑制细胞周期蛋白依赖性激酶4/细胞周期蛋白D1。
Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1.
作者信息
Jeong H W, Kim M R, Son K H, Han M Y, Ha J H, Garnier M, Meijer L, Kwon B M
机构信息
Korea Research Institute of Bioscience and Biotechnology, KIST, Taejon, South Korea.
出版信息
Bioorg Med Chem Lett. 2000 Aug 21;10(16):1819-22. doi: 10.1016/s0960-894x(00)00357-7.
Abstract
A series of cinnamaldehydes was synthesized for the study of inhibitory activity against cyclin dependent kinases (CDKs). A couple of compounds selectively inhibited cyclin D1-CDK4 with an IC50 value of 7-18 microM.
摘要
合成了一系列肉桂醛用于研究其对细胞周期蛋白依赖性激酶（CDK）的抑制活性。有几种化合物以7 - 18微摩尔的半数抑制浓度（IC50）值选择性地抑制细胞周期蛋白D1 - CDK4。
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