Deuschl G, Wenzelburger R, Raethjen J
Department of Neurology, Christian-Albrechts-Universität, Kiel, Germany.
Curr Opin Neurol. 2000 Aug;13(4):437-43. doi: 10.1097/00019052-200008000-00012.
Tremor research during the past year has focused on clinical differential diagnosis, and a new clinical classification has been developed. The origin of tremor is thought to depend on unstable central loops, and new coherence data suggest that these often involve the motor cortex. Gabapentine has been assessed for efficacy in some tremors, and deep brain stimulation of the ventrolateral thalamus has been shown to be safer and more effective for severe essential and parkinsonian tremor than thalamotomy.
过去一年里,震颤研究主要集中在临床鉴别诊断方面,并且已经形成了一种新的临床分类。震颤的起源被认为取决于不稳定的中枢环路,新的相干性数据表明这些环路通常涉及运动皮层。已经评估了加巴喷丁对某些震颤的疗效,并且已经证明,对于严重的特发性震颤和帕金森病震颤,丘脑腹外侧核的深部脑刺激比丘脑切开术更安全、更有效。