Tilz Christian, Wang-Tilz Ying
Epilepsy Center Bodensee, Clinik of Neurology and Epileptology, ZfP Südwürttemberg, Weingartshofer Str. 2, 88214 Ravensburg, Germany.
Department of Neurology, University Hospital of Graz, Univesity Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
J Clin Med. 2025 Apr 15;14(8):2716. doi: 10.3390/jcm14082716.
Epilepsy and Parkinson's disease (PD) are two common neurological disorders, with a lifetime prevalence of approximately 1% and 0.4%, respectively. Both conditions affect movement and brain function and were traditionally considered distinct, with different pathophysiological mechanisms. However, recent research suggests potential links between them. Some studies indicate that epilepsy may contribute to the development of PD due to chronic neuroinflammation, excitotoxicity, and neuronal loss. Conversely, PD-related neurodegeneration in dopaminergic pathways might increase susceptibility to seizures. This article presents a narrative review of the limited literature on the pathophysiological mechanisms linking epilepsy and PD, including shared genetic factors, neurodegenerative processes, and alterations in the neurotransmitter system. It also examines the influence of anti-seizure medications and dopaminergic treatments on the symptoms and progression of both disorders, as well as their common clinical features. Additionally, the limitations of the existing data on this topic are discussed. Understanding the true relationship between these two disorders is crucial, as it could provide insight into common neurobiological mechanisms and lead to improved therapeutic strategies.
癫痫和帕金森病（PD）是两种常见的神经系统疾病，终生患病率分别约为1%和0.4%。这两种疾病都会影响运动和脑功能，传统上被认为是不同的，具有不同的病理生理机制。然而，最近的研究表明它们之间存在潜在联系。一些研究表明，由于慢性神经炎症、兴奋性毒性和神经元丢失，癫痫可能导致PD的发生。相反，多巴胺能通路中与PD相关的神经退行性变可能会增加癫痫发作的易感性。本文对关于癫痫和PD之间病理生理机制的有限文献进行了叙述性综述，包括共同的遗传因素、神经退行性变过程以及神经递质系统的改变。它还研究了抗癫痫药物和多巴胺能治疗对这两种疾病症状和进展的影响，以及它们的共同临床特征。此外，还讨论了关于该主题现有数据的局限性。了解这两种疾病之间的真正关系至关重要，因为它可以深入了解共同的神经生物学机制，并带来改进的治疗策略。
