van Meeteren N L, Brakkee J H, Helders P J, Gispen W H
Rudolf Magnus Institute for Neurosciences, Utrecht University, Faculty of Medicine, Department of Medical Pharmacology, The Netherlands.
J Peripher Nerv Syst. 1998;3(4):277-82.
Two separate experiments were carried out in order to evaluate the influence of moderate swim training and treadmill running on the rate of recovery of sensorimotor function following sciatic nerve injury in the rat. Nerve injury was induced by sciatic nerve crush. In the first experiment, rats were subjected to swim exercise (180 m daily), either for 7 days before, or for 14 consecutive days after nerve injury. In the second experiment rats were exercised on a motor driven treadmill device (10 m/min for 30 min twice daily) for 21 days. The recovery from nerve injury was assessed by means of an analysis of the free walking pattern (motor function) and the foot withdrawal reflex (sensory function) by electrical stimulation. The swim training program before or after crush did not affect the recovery of locomotor or sensory function. Treadmill running significantly deteriorated the gradual return of motor function (p < 0.05), but did not influence sensory recovery. We conclude that swim training does not interfere with functional sensorimotor recovery after sciatic nerve injury, and that a mild program of treadmill running retards recovery. We hypothesize that the retardation of recovery as a result of treadmill running is the consequence of the stress inflicted by the negative reinforcement used in the treadmill, or due to the severity of the training. /Ø?>
为了评估适度游泳训练和跑步机跑步对大鼠坐骨神经损伤后感觉运动功能恢复速率的影响，进行了两项独立实验。通过坐骨神经挤压诱导神经损伤。在第一个实验中，大鼠进行游泳运动（每天180米），要么在神经损伤前7天进行，要么在神经损伤后连续14天进行。在第二个实验中，大鼠在电动跑步机装置上运动（每分钟10米，每天两次，每次30分钟），持续21天。通过分析自由行走模式（运动功能）和电刺激引起的足部退缩反射（感觉功能）来评估神经损伤的恢复情况。挤压前或挤压后的游泳训练计划均未影响运动或感觉功能的恢复。跑步机跑步显著延缓了运动功能的逐渐恢复（p < 0.05），但不影响感觉恢复。我们得出结论，游泳训练不会干扰坐骨神经损伤后的功能性感觉运动恢复，而轻度的跑步机跑步计划会延缓恢复。我们推测，跑步机跑步导致恢复延缓是跑步机中使用的负强化施加的压力的结果，或者是由于训练的强度。
