Volpe G, Della Rocca G, Brescia Morra V, Belfiore G, Coppola G, Campanella G, Orefice G
Department of Neurological Sciences, University Federico II, Naples, Italy.
Eur J Neurol. 2000 Jul;7(4):401-4. doi: 10.1046/j.1468-1331.2000.00080.x.
Primitive reflexes (PRs) are present in newborns; they disappear as the brain matures and increase in frequency in healthy elderly individuals. Primitive reflexes are more frequent in some neurological disorders than in age-matched controls. The aim of this study was to investigate the effect of diabetes on some PRs. We examined three PRs (glabellar tap, snout and palmomental reflexes) in 376 subjects: 111 normal age-matched controls, 60 patients with cerebrovascular disease (CVD) and 205 patients with type 2 diabetes mellitus. The latter patients were divided into three groups: (1) diabetics without neurological complications (D); (2) diabetics with cerebrovascular disease (D-CVD); and (3) diabetics with polyneuropathy (D-PN). The frequency of PRs was increased in CVD, unchanged in D-CVD (except palmomental) and greatly reduced in D and D-PN. It is possible that the vascular lesions in perforating arteries of the pons in diabetic subjects, previously studied in some pathological reports, can account for the reduced occurrence of primitive reflex responses.
原始反射（PRs）在新生儿中存在；随着大脑成熟，它们会消失，而在健康老年人中出现频率增加。在某些神经系统疾病中，原始反射比年龄匹配的对照组更频繁。本研究的目的是调查糖尿病对某些原始反射的影响。我们在376名受试者中检查了三种原始反射（眉间轻叩、噘嘴和掌颏反射）：111名年龄匹配的正常对照组、60名脑血管疾病（CVD）患者和205名2型糖尿病患者。后一组患者分为三组：（1）无神经并发症的糖尿病患者（D）；（2）患有脑血管疾病的糖尿病患者（D-CVD）；（3）患有多发性神经病变的糖尿病患者（D-PN）。原始反射的频率在CVD中增加，在D-CVD中不变（掌颏反射除外），在D组和D-PN组中大幅降低。先前在一些病理报告中研究过的糖尿病患者脑桥穿通动脉的血管病变，可能是原始反射反应发生率降低的原因。
