Spicka I, Klener P
I. interní klinika 1. LF UK a VFN, Praha.
Cas Lek Cesk. 2000 Jul 5;139(13):391-5.
The triad of clinical features describes multiple myeloma: the accumulation of malignant plasma cell in the bone marrow, paraprotein production and bone involvement. Moreover, number of characteristic and frequently specific complications may develop during the course of disease. Identification of new prognostic factors may be helpful for the choice of therapy. The prognosis of patients has improved since the introduction of new therapeutic approaches, however, multiple myeloma is still mostly fatal malignancy. The clinical and laboratory characteristic of myeloma and differential diagnosis of disease are described. The results of contemporary therapy and future therapeutic approaches are also discussed.
骨髓中恶性浆细胞的积聚、副蛋白产生和骨骼受累。此外，在疾病过程中可能会出现一些特征性且通常较为特异的并发症。识别新的预后因素可能有助于治疗方案的选择。自从引入新的治疗方法以来，患者的预后有所改善，然而，多发性骨髓瘤仍然是主要的致命性恶性肿瘤。本文描述了骨髓瘤的临床和实验室特征以及疾病的鉴别诊断。还讨论了当代治疗的结果和未来的治疗方法。
