使用电感耦合等离子体质谱法对发生器产生的高锝酸盐中的锝进行定量分析。

The quantification of technetium in generator-derived pertechnetate using ICP-MS.

作者信息

Hill D M, Barnes R K, Wong H K, Zawadzki A W

机构信息

Australian Nuclear Science and Technology Organisation Menai, NSW.

出版信息

Appl Radiat Isot. 2000 Sep;53(3):415-9. doi: 10.1016/s0969-8043(99)00280-8.

DOI:10.1016/s0969-8043(99)00280-8

PMID:10972146

Abstract

Previous analytical methods employed to measure 99Tc:99mTc ratios in chromatographic 99mTc generators, derived from fission-based 99Mo, were limited in monitoring the ratios in low activity generators, over the extent of their elution regimes. For regulatory purposes, ICP-MS was employed to measure total technetium in generator eluates down to a level of 200 pg ml(-1) (200 ppt). Measured 99Tc:99mTc ratios compared very well with the theoretically computed values, ranging from 47:1 for a first elution of a generator with a long ingrowth time to 1.4:1 for the 17th elution of a generator with a short ingrowth time.

摘要

以往用于测量基于裂变产生的99Mo的色谱法99mTc发生器中99Tc:99mTc比率的分析方法，在监测低活度发生器洗脱范围内的比率时存在局限性。出于监管目的，采用电感耦合等离子体质谱法（ICP-MS）测量发生器洗脱液中的总锝，检测下限可达200 pg ml(-1)（200 ppt）。测得的99Tc:99mTc比率与理论计算值非常吻合，范围从生长时间长的发生器首次洗脱时的47:1到生长时间短的发生器第17次洗脱时的1.4:1。