使用闪烁探测系统优化 99mTc 洗脱液样品中的 99Mo 测量。

Optimization of 99Mo measurement in 99mTc eluate samples using a scintillation detection system.

机构信息

Instituto de Radioproteção e Dosimetria (IRD-CNEN), Av. Salvador Allende, s/n-22780-160, Rio de Janeiro, Brazil.

出版信息

Health Phys. 2010 Oct;99(4):453-6. doi: 10.1097/HP.0b013e3181c1cbd6.

PMID:20838085

Abstract

During elution of 99Mo-99mTc generators used in nuclear medicine, 99Mo might be extracted becoming a radionuclidic impurity. According to the International Atomic Energy Agency, the activity ratio between 99Mo and 99mTc in the eluate, at the moment of administration to the patient, should not exceed 0.015%. The aim of this work is to optimize a methodology to determine 99Mo activity in 99mTc eluates. Efficiency curves were obtained using a NaI(Tl)8"×4" scintillation detector. The methodology was validated by measuring a standard solution of 99Mo. It was concluded that the technique is sensitive to detect 99Mo in 99mTc eluates at levels below international limits.

摘要

在核医学中使用的 99Mo-99mTc 发生器洗脱时，99Mo 可能会被提取出来成为放射性核素杂质。根据国际原子能机构的规定，在向患者给药时，洗脱液中 99Mo 与 99mTc 的活度比不应超过 0.015%。本工作旨在优化一种测定 99mTc 洗脱液中 99Mo 活度的方法。使用 NaI(Tl)8"×4" 闪烁探测器获得效率曲线。通过测量 99Mo 标准溶液对该方法进行了验证。结果表明，该技术能够灵敏地检测到低于国际限量的 99mTc 洗脱液中的 99Mo。