Andrews K, Francis D J, Riese M L
Department of Psychiatry, Southern Illinois University School of Medicine, Carbondale, Illinois 62901-6503, USA.
J Dev Behav Pediatr. 2000 Aug;21(4):262-70. doi: 10.1097/00004703-200008000-00002.
The consequences of prematurity and prenatal cocaine exposure on early neurobehavior and physical growth were examined longitudinally in a sample of 20 cocaine-exposed and 20 non-exposed preterm neonates. The magnitude of the difference in physical growth acceleration related to prenatal cocaine exposure increased with increasing birth gestational age, whereas growth rate differences in irritability decreased. In contrast, prenatal cocaine exposure, independent of prematurity, was related to reduced attention skills at 36 weeks conceptional age and increased rates of neurobehavioral change. The effects of prenatal cocaine exposure differed with respect to the degree of prematurity, depending on the nature of the outcome examined, suggesting differing windows of vulnerability for different outcome domains. The usefulness of a developmental growth perspective was demonstrated.
对20名暴露于可卡因的早产新生儿和20名未暴露于可卡因的早产新生儿样本进行了纵向研究，以考察早产和产前可卡因暴露对早期神经行为和身体发育的影响。与产前可卡因暴露相关的身体生长加速差异程度随出生孕周增加而增大，而易怒性方面的生长速率差异则减小。相比之下，产前可卡因暴露（与早产无关）与孕龄36周时注意力技能降低及神经行为变化率增加有关。产前可卡因暴露的影响因早产程度而异，具体取决于所考察结果的性质，这表明不同结果领域的易损窗口期不同。研究证明了发展性生长视角的有用性。
