由痘病毒和疱疹病毒编码的宿主相关免疫调节剂。

Host-related immunomodulators encoded by poxviruses and herpesviruses.

作者信息

McFadden G, Murphy P M

机构信息

The John P Robarts Research Institute, and Department of Microbiology and Immunology, The University of Western Ontario, London, Canada.

出版信息

Curr Opin Microbiol. 2000 Aug;3(4):371-8. doi: 10.1016/s1369-5274(00)00107-7.

DOI:10.1016/s1369-5274(00)00107-7

PMID:10972497

Abstract

In the past year, important advances have been made in the area of host-related immunomodulatory genes encoded by the larger DNA viruses, particularly for the poxviruses and herpesviruses. Not only has the repertoire of viral immunomodulator homologs expanded as a result of sequencing the complete genome of another six, large DNA viruses, but also new concepts of how they work have been proposed and in some cases supported by in vivo evidence. Recent developments have been made in understanding a spectrum of host-related viral modulators, including complement control proteins, TNF-receptor homologs, IL-18 binding proteins, viral interleukins (vIL-6 and vIL-10), chemokine mimics and chemokine receptor homologs.

摘要

在过去一年中，由较大DNA病毒编码的宿主相关免疫调节基因领域取得了重要进展，特别是痘病毒和疱疹病毒方面。由于对另外六种大型DNA病毒的全基因组进行了测序，病毒免疫调节剂同源物的种类不仅有所增加，而且还提出了关于它们如何发挥作用的新观念，并且在某些情况下得到了体内证据的支持。在理解一系列宿主相关病毒调节剂方面取得了最新进展，这些调节剂包括补体控制蛋白、肿瘤坏死因子受体同源物、白细胞介素-18结合蛋白、病毒白细胞介素（vIL-6和vIL-10）、趋化因子模拟物和趋化因子受体同源物。