Stoica E, Enulescu O, Gheorghiu M
Eur Neurol. 1975;13(4):285-303. doi: 10.1159/000114684.
A method of treatment consisting in administration of a neurodynamic drug, pyrithioxin, combined with a short period of hyperventilation (HV) was applied in cerebral infarct patients with hemiplegia. The combination was superior to pyrithioxin alone for the motor recovery of these patients. In some cases, it induced immediately a partial restoration of motility. The combination constantly brought about an increase in urinary excretion of norepinephrine and vanilmandelic acid, which failed to occur after pyrithioxin or HV alone. HV appears to facilitate the neural effects of the drug by promoting its transfer into the CNS.
一种治疗方法是对患有偏瘫的脑梗死患者使用神经动力学药物吡硫醇，并结合短时间的过度换气（HV）。对于这些患者的运动恢复，这种联合治疗比单独使用吡硫醇更有效。在某些情况下，它能立即促使运动能力部分恢复。这种联合治疗持续导致去甲肾上腺素和香草扁桃酸的尿排泄增加，而单独使用吡硫醇或HV后并未出现这种情况。过度换气似乎通过促进药物向中枢神经系统的转运来增强药物的神经作用。
