细胞分裂增加而非胸腺功能障碍迅速影响HIV-1感染中初始T细胞群体的T细胞受体切除环含量。

Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection.

作者信息

Hazenberg M D, Otto S A, Cohen Stuart J W, Verschuren M C, Borleffs J C, Boucher C A, Coutinho R A, Lange J M, Rinke de Wit T F, Tsegaye A, van Dongen J J, Hamann D, de Boer R J, Miedema F

机构信息

Department of Clinical Viro-Immunology, CLB, and the Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands.

出版信息

Nat Med. 2000 Sep;6(9):1036-42. doi: 10.1038/79549.

DOI:10.1038/79549

PMID:10973325

Abstract

Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs have been observed with aging and in human immunodeficiency virus (HIV)-1 infected individuals, suggesting thymic impairment. Here, we show that in healthy individuals, declining thymic output will affect the TREC content only when accompanied by naive T-cell division. The rapid decline in TRECs observed during HIV-1 infection and the increase following HAART are better explained not by thymic impairment, but by changes in peripheral T-cell division rates. Our data indicate that TREC content in healthy individuals is only indirectly related to thymic output, and in HIV-1 infection is mainly affected by immune activation.

摘要

近期胸腺迁出细胞可通过T细胞受体重排过程中形成的T细胞受体切除环（TRECs）来识别。随着年龄增长以及在人类免疫缺陷病毒（HIV）-1感染个体中，已观察到TRECs数量减少，提示胸腺功能受损。在此，我们表明，在健康个体中，仅当伴有初始T细胞分裂时，胸腺输出的下降才会影响TREC含量。在HIV-1感染期间观察到的TRECs快速下降以及高效抗逆转录病毒治疗（HAART）后的增加，更好的解释不是胸腺功能受损，而是外周T细胞分裂速率的变化。我们的数据表明，健康个体中的TREC含量仅与胸腺输出间接相关，而在HIV-1感染中主要受免疫激活影响。