• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Genetic and environmental effects in paroxysmal nocturnal hemoglobinuria: this little PIG-A goes "Why? Why? Why?".

作者信息

Young N S, Maciejewski J P

机构信息

Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA.

出版信息

J Clin Invest. 2000 Sep;106(5):637-41. doi: 10.1172/JCI11002.

DOI:10.1172/JCI11002
PMID:10974016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC381297/
Abstract
摘要

相似文献

1
Genetic and environmental effects in paroxysmal nocturnal hemoglobinuria: this little PIG-A goes "Why? Why? Why?".阵发性睡眠性血红蛋白尿症中的遗传和环境影响：这只小小的PIG-A基因在问“为什么？为什么？为什么？”
J Clin Invest. 2000 Sep;106(5):637-41. doi: 10.1172/JCI11002.
2
[Differentiation of hematopoietic stem cell and expression of GPI-anchor protein in paroxysmal nocturnal hemoglobinuria].[阵发性睡眠性血红蛋白尿症中造血干细胞的分化及糖基磷脂酰肌醇锚定蛋白的表达]
Nihon Naika Gakkai Zasshi. 1996 Jul 10;85(7):1160-4.
3
On the origin of multiple mutant clones in paroxysmal nocturnal hemoglobinuria.阵发性夜间血红蛋白尿中多个突变克隆的起源
Stem Cells. 2007 Dec;25(12):3081-4. doi: 10.1634/stemcells.2007-0427. Epub 2007 Sep 6.
4
[Paroxysmal nocturnal hemoglobinuria: pathogenic and therapeutic news].[阵发性夜间血红蛋白尿：致病与治疗新进展]
An Med Interna. 2001 Aug;18(8):435-9.
5
Paroxysmal nocturnal hemoglobinuria and complement-mediated erythrocyte damage.阵发性夜间血红蛋白尿与补体介导的红细胞损伤。
Curr Opin Hematol. 1994 Mar;1(2):151-6.
6
Differential gene expression in hematopoietic progenitors from paroxysmal nocturnal hemoglobinuria patients reveals an apoptosis/immune response in 'normal' phenotype cells.阵发性夜间血红蛋白尿患者造血祖细胞中的差异基因表达揭示了“正常”表型细胞中的凋亡/免疫反应。
Leukemia. 2005 May;19(5):862-8. doi: 10.1038/sj.leu.2403678.
7
[Expression of GPI-anchor proteins during the differentiation from hematopoietic progenitors in patients with paroxysmal nocturnal hemoglobinuria].
Rinsho Ketsueki. 1994 Apr;35(4):358-63.
8
[Paroxysmal nocturnal hemoglobinuria].阵发性夜间血红蛋白尿
Nihon Rinsho. 2005 May;63 Suppl 5:454-9.
9
[Membrane defects in paroxysmal nocturnal hemoglobinuria].[阵发性夜间血红蛋白尿中的膜缺陷]
Haematologica. 1991 Jun;76 Suppl 3:207-12.
10
[Paroxysmal nocturnal hemoglobinuria].[阵发性夜间血红蛋白尿]
Nihon Rinsho. 1991 Mar;49(3):667-71.

引用本文的文献

1
Hairy Cell Leukemia: A Differential Diagnosis of Hepatitis B-Associated Aplastic Anemia and Syphilis.毛细胞白血病：与乙型肝炎相关的再生障碍性贫血和梅毒的鉴别诊断
Hematol Rep. 2025 Mar 15;17(2):13. doi: 10.3390/hematolrep17020013.
2
Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition.成人原发性免疫性血小板减少症诊断参考指南，2023 年版。
Int J Hematol. 2024 Jan;119(1):1-13. doi: 10.1007/s12185-023-03672-1. Epub 2023 Nov 13.
3
Clonal evolution in aplastic anemia: failed tumor surveillance or maladaptive recovery?再生障碍性贫血中的克隆进化：肿瘤监测失败还是适应性恢复不良？
Leuk Lymphoma. 2023 Jul-Aug;64(8):1389-1399. doi: 10.1080/10428194.2023.2215614. Epub 2023 Jun 25.
4
Clonality in immune aplastic anemia: Mechanisms of immune escape or malignant transformation.免疫性再生障碍性贫血中的克隆性：免疫逃逸或恶性转化的机制。
Semin Hematol. 2022 Jul;59(3):137-142. doi: 10.1053/j.seminhematol.2022.08.001. Epub 2022 Aug 12.
5
Clinical and Molecular Determinants of Clonal Evolution in Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria.再生障碍性贫血和阵发性睡眠性血红蛋白尿症中克隆进化的临床和分子决定因素。
J Clin Oncol. 2023 Jan 1;41(1):132-142. doi: 10.1200/JCO.22.00710. Epub 2022 Sep 2.
6
Hypoplastic myelodysplastic syndrome and acquired aplastic anemia: Immune‑mediated bone marrow failure syndromes (Review).发育不全性骨髓增生异常综合征和获得性再生障碍性贫血：免疫介导的骨髓衰竭综合征（综述）。
Int J Oncol. 2022 Jan;60(1). doi: 10.3892/ijo.2021.5297. Epub 2021 Dec 27.
7
The similarity of class II HLA genotypes defines patterns of autoreactivity in idiopathic bone marrow failure disorders.Ⅱ类 HLA 基因型的相似性定义了特发性骨髓衰竭疾病中自身反应的模式。
Blood. 2021 Dec 30;138(26):2781-2798. doi: 10.1182/blood.2021012900.
8
Idiopathic aplastic anemia vs hypocellular myelodysplastic syndrome.特发性再生障碍性贫血与低细胞性骨髓增生异常综合征。
Hematology Am Soc Hematol Educ Program. 2019 Dec 6;2019(1):97-104. doi: 10.1182/hematology.2019000019.
9
CRISPR/Cas9 gene editing in nonhuman primate model demonstrates no intrinsic clonal expansion of PNH HSPCs.在非人灵长类动物模型中的CRISPR/Cas9基因编辑表明，阵发性睡眠性血红蛋白尿症造血干细胞不存在内在的克隆性扩增。
Blood. 2019 Jun 6;133(23):2542-2545. doi: 10.1182/blood.2019000800. Epub 2019 Apr 19.
10
Expanding Complement Therapeutics for the Treatment of Paroxysmal Nocturnal Hemoglobinuria.阵发性睡眠性血红蛋白尿症治疗中补体疗法的拓展。
Semin Hematol. 2018 Jul;55(3):167-175. doi: 10.1053/j.seminhematol.2018.02.002. Epub 2018 Feb 14.

本文引用的文献

1
Impaired growth and elevated fas receptor expression in PIGA(+) stem cells in primary paroxysmal nocturnal hemoglobinuria.原发性阵发性夜间血红蛋白尿症中PIGA(+)干细胞生长受损及Fas受体表达升高
J Clin Invest. 2000 Sep;106(5):689-96. doi: 10.1172/JCI8328.
2
HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine.热休克蛋白70（HSP70）通过一种依赖于CD14的途径刺激细胞因子的产生，这表明了它作为伴侣蛋白和细胞因子的双重作用。
Nat Med. 2000 Apr;6(4):435-42. doi: 10.1038/74697.
3
Immunosuppressive treatment of aplastic anemia with antithymocyte globulin and cyclosporine.使用抗胸腺细胞球蛋白和环孢素对再生障碍性贫血进行免疫抑制治疗。
Semin Hematol. 2000 Jan;37(1):56-68. doi: 10.1016/s0037-1963(00)90030-1.
4
Cytotoxicity against lymphoblastoid cells mediated by a T-cell clone from an aplastic anaemia patient: role of CD59 on target cells.再生障碍性贫血患者T细胞克隆介导的对淋巴母细胞的细胞毒性：CD59在靶细胞上的作用。
Br J Haematol. 1999 Dec;107(4):791-6. doi: 10.1046/j.1365-2141.1999.01790.x.
5
Paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure syndromes.骨髓衰竭综合征患者中的阵发性睡眠性血红蛋白尿细胞
Ann Intern Med. 1999 Sep 21;131(6):401-8. doi: 10.7326/0003-4819-131-6-199909210-00002.
6
High incidence of transiently appearing complement-sensitive bone marrow precursor cells in patients with severe aplastic anemia--A possible role of high endogenous IL-2 in their suppression.重型再生障碍性贫血患者中短暂出现的补体敏感骨髓前体细胞的高发生率——内源性白细胞介素-2升高在其抑制中的可能作用
Acta Haematol. 1999;101(4):165-72. doi: 10.1159/000040948.
7
The PIG-A mutation and absence of glycosylphosphatidylinositol-linked proteins do not confer resistance to apoptosis in paroxysmal nocturnal hemoglobinuria.阵发性睡眠性血红蛋白尿症中的PIG-A突变及糖基磷脂酰肌醇连接蛋白缺失并不赋予细胞对凋亡的抗性。
Blood. 1998 Oct 1;92(7):2541-50.
8
The pathophysiology of acquired aplastic anemia.获得性再生障碍性贫血的病理生理学。
N Engl J Med. 1997 May 8;336(19):1365-72. doi: 10.1056/NEJM199705083361906.
9
Impaired hematopoiesis in paroxysmal nocturnal hemoglobinuria/aplastic anemia is not associated with a selective proliferative defect in the glycosylphosphatidylinositol-anchored protein-deficient clone.阵发性睡眠性血红蛋白尿/再生障碍性贫血中造血功能受损与糖基磷脂酰肌醇锚定蛋白缺陷克隆中的选择性增殖缺陷无关。
Blood. 1997 Feb 15;89(4):1173-81.
10
Somatic mutations in paroxysmal nocturnal hemoglobinuria: a blessing in disguise?阵发性夜间血红蛋白尿中的体细胞突变：因祸得福？
Cell. 1997 Jan 10;88(1):1-4. doi: 10.1016/s0092-8674(00)81850-4.