Lymphocyte peripheral benzodiazepine receptor mRNA decreases in obsessive-compulsive disorder.
作者信息
Rocca P, Beoni A M, Eva C, Ferrero P, Maina G, Bogetto F, Ravizza L
机构信息
Department of Neuroscience, Section of Psychiatry, University of Turin, via Cherasco 11, 10126 Torino, Italy.
出版信息
Eur Neuropsychopharmacol. 2000 Sep;10(5):337-40. doi: 10.1016/s0924-977x(00)00091-2.
The relative content of peripheral benzodiazepine receptor (pBR) mRNA was examined by reverse transcriptase-polymerase chain reaction in lymphocytes of obsessive-compulsive disorder (OCD) patients, according to their clinical course of illness. pBR mRNA significantly decreased only in chronic OCD patients (n=8) as compared to controls (n=10), whereas no significant changes were observed in episodic OCD patients (n=7). We suggest that modulation of pBR gene expression might delineate a clinical heterogeneity in OCD.
Zotero 插件