喂食维生素A缺乏饮食和视黄酸处理对棕色脂肪组织解偶联蛋白1（UCP1）、UCP2和瘦素表达的相反影响。
Opposite effects of feeding a vitamin A-deficient diet and retinoic acid treatment on brown adipose tissue uncoupling protein 1 (UCP1), UCP2 and leptin expression.
作者信息
Bonet M L, Oliver J, Picó C, Felipe F, Ribot J, Cinti S, Palou A
机构信息
Laboratori de Biologia Molecular, Nutrició i Biotecnologia, Departamento Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Crta. Valldemossa Km 7.5, 07071 Palma de Mallorca, Spain.
出版信息
J Endocrinol. 2000 Sep;166(3):511-7. doi: 10.1677/joe.0.1660511.
The relationship between interscapular brown adipose tissue (IBAT) thermogenic potential and vitamin A status was investigated by studying the effects of feeding a vitamin A-deficient diet and all-trans retinoic acid (tRA) treatment on body weight and IBAT parameters in mice. Feeding a vitamin A-deficient diet tended to trigger opposite effects to those of tRA treatment, namely increased body weight, IBAT weight, adiposity and leptin mRNA expression, and reduced IBAT thermogenic potential in terms of uncoupling protein 1 (UCP1) mRNA and UCP2 mRNA expression. The results emphasize the importance of retinoids as physiological regulators of brown adipose tissue.
通过研究喂食维生素A缺乏饮食和全反式维甲酸（tRA）处理对小鼠体重和肩胛间棕色脂肪组织（IBAT）参数的影响，探讨了IBAT产热潜能与维生素A状态之间的关系。喂食维生素A缺乏饮食往往会引发与tRA处理相反的效果，即体重增加、IBAT重量增加、肥胖和瘦素mRNA表达增加，以及就解偶联蛋白1（UCP1）mRNA和UCP2 mRNA表达而言，IBAT产热潜能降低。结果强调了类视黄醇作为棕色脂肪组织生理调节因子的重要性。
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